DKK3 initially preserves acinar integrity through MEK-Fos signaling, but later switches to an oncogenic role in pancreatic cancer.
D. Srinivasan, E. Roger, L. Perkhofer, E. Zimmer, T.F.E. Barth, J.P. Mosler, A. Härle, S.E. Weissinger, N.T. Gaisa, P. Möller, N. Fischer, C. Allgöwer, J-M. Löhr, D. Grimm, T. Seufferlein, S. Liebau, N. Azoitei, M.K. Melzer, F. Arnold, J. Gout, A. Kleger. 2026. Adv Sci (Weinh).
D. Srinivasan, E. Roger, L. Perkhofer, E. Zimmer, T.F.E. Barth, J.P. Mosler, A. Härle, S.E. Weissinger, N.T. Gaisa, P. Möller, N. Fischer, C. Allgöwer, J-M. Löhr, D. Grimm, T. Seufferlein, S. Liebau, N. Azoitei, M.K. Melzer, F. Arnold, J. Gout, A. Kleger. 2026. Adv Sci (Weinh).
Exploiting TGF-β-mediated stromal programming in homologous recombination-deficient pancreatic cancer.
E. Roger, H.M. Mummey, E. Zimmer, D. Srinivasan, A. Härle, L. Moubri, A.K. Beutel, R. Singh, M. Ekizce, M.K. Melzer, Y. Lee, A. Silva, L. Härle, T. Engleitner, F. Arnold, M. Morawe, B. Naggay, J. Schneider, L. Gilberg, J.P. Mosler, C. Ludwig, C. Meng, M. Hirschenberger, V. Hunszinger, K. Kluck, M. Kirchner, A-L. Volckmar, M. Wirth, M.S.S. Alhmadani, J.D. Hoheisel, J-M. Löhr, T. Seufferlein, A. Abaei. R. Kemkemer, R. Rad, J. Budczies, M.A. Mulaw, P.C. Hermann, M. Hänle, K.M.J. Sparrer, C.J. Halbrook, K.J. Gaulton, K. Steinestel, A. Stenzinger, N. Dusetti, L. Perkhofer, J. Gout, A. Kleger. 2025. Preprint. Biorxiv.
E. Roger, H.M. Mummey, E. Zimmer, D. Srinivasan, A. Härle, L. Moubri, A.K. Beutel, R. Singh, M. Ekizce, M.K. Melzer, Y. Lee, A. Silva, L. Härle, T. Engleitner, F. Arnold, M. Morawe, B. Naggay, J. Schneider, L. Gilberg, J.P. Mosler, C. Ludwig, C. Meng, M. Hirschenberger, V. Hunszinger, K. Kluck, M. Kirchner, A-L. Volckmar, M. Wirth, M.S.S. Alhmadani, J.D. Hoheisel, J-M. Löhr, T. Seufferlein, A. Abaei. R. Kemkemer, R. Rad, J. Budczies, M.A. Mulaw, P.C. Hermann, M. Hänle, K.M.J. Sparrer, C.J. Halbrook, K.J. Gaulton, K. Steinestel, A. Stenzinger, N. Dusetti, L. Perkhofer, J. Gout, A. Kleger. 2025. Preprint. Biorxiv.
Tumor microenvironment subtyping in pancreatic ductal adenocarcinoma: new avenues for personalized therapeutic strategies.
D. Srinivasan, J. Gout, A. Kleger, E. Roger. 2025. Adv Drug Deliv Rev.
D. Srinivasan, J. Gout, A. Kleger, E. Roger. 2025. Adv Drug Deliv Rev.
Homologous repair-deficient pancreatic cancer: refined targeting of DNA damage response is an effective therapeutic strategy.
A.K. Beutel, C.J. Halbrook, M. Ekizce, J. Lindenmayer, E. Roger, S.E. Calderon, T. Seufferlein, A. Kleger, J. Gout, L. Perkhofer. 2025. United European Gastroenterol J.
A.K. Beutel, C.J. Halbrook, M. Ekizce, J. Lindenmayer, E. Roger, S.E. Calderon, T. Seufferlein, A. Kleger, J. Gout, L. Perkhofer. 2025. United European Gastroenterol J.
Pancreatic organoids as cancer avatars for true personalized medicine.
J.Gout, M. Ekizce, E. Roger, A. Kleger. 2025. Adv Drug Deliv Rev.
J.Gout, M. Ekizce, E. Roger, A. Kleger. 2025. Adv Drug Deliv Rev.
Pancreatic cancer patient-derived organoids capture therapy response and tumor evolution.
J. Gout, L. Perkhofer, J. Lindenmayer, Y.J. Resheq, J.D. Schwab, J.M. Kraus, E. Roger, D. Srinivasan, E. Zimmer, B. Mayer, R. Marienfeld, N.T. Gaisa, J.K. Kühlwein, M. Hänle, T.J. Ettrich, M. Danzer, A.K. Beutel, B. Kong, C. Michalski, A.L. Mihaljevic, N.N. Rahbari, M. Kornmann, H.A. Kestler, T. Seufferlein, A. Kleger. 2025. Preprint. Biorxiv.
J. Gout, L. Perkhofer, J. Lindenmayer, Y.J. Resheq, J.D. Schwab, J.M. Kraus, E. Roger, D. Srinivasan, E. Zimmer, B. Mayer, R. Marienfeld, N.T. Gaisa, J.K. Kühlwein, M. Hänle, T.J. Ettrich, M. Danzer, A.K. Beutel, B. Kong, C. Michalski, A.L. Mihaljevic, N.N. Rahbari, M. Kornmann, H.A. Kestler, T. Seufferlein, A. Kleger. 2025. Preprint. Biorxiv.
Unveiling the intriguing relationship: oncogenic KRAS, morphological shifts, and mutational complexity in pancreatic mucinous cystic neoplasms.
L.A. Schulte, A. Beck, R. Marienfeld, N. Azoitei, T.F.E.Barth, A. Beutel, V. Benes, M.W. Büchler, N.T. Gaisa, K. Kilani, N. Giese, C.W. Michalski, P. Möller, L. Perkhofer, T. Rausch, S. Repky, E. Roger, J. Scheible, T. Seufferlein, P. Schirmacher, A.W. Berger, T. Hackert, A. Kleger. 2025. J Pathol.
L.A. Schulte, A. Beck, R. Marienfeld, N. Azoitei, T.F.E.Barth, A. Beutel, V. Benes, M.W. Büchler, N.T. Gaisa, K. Kilani, N. Giese, C.W. Michalski, P. Möller, L. Perkhofer, T. Rausch, S. Repky, E. Roger, J. Scheible, T. Seufferlein, P. Schirmacher, A.W. Berger, T. Hackert, A. Kleger. 2025. J Pathol.
A methodological workflow to analyze synthetic lethality and drug synergism in cancer cells.
J.Gout, E. Roger, A. Kleger, L. Perkhofer. 2022. Method Mol Biol.
J.Gout, E. Roger, A. Kleger, L. Perkhofer. 2022. Method Mol Biol.
State-matched organoid models to fight pancreatic cancer.
M.K. Melzer, E. Roger, A. Kleger. 2022. Trends Cancer.
M.K. Melzer, E. Roger, A. Kleger. 2022. Trends Cancer.
Organoids at the PUB: the porcine urinary bladder serves as pancreatic niche for advanced cancer modeling.
M.K. Melzer, M. Breunig, F. Arnold, F. Wezel, A. Azoitei, E. Roger, J. Krüger, J. Merkle, L. Schütte, Y. Resheq, M. Hänle, V. Zehe, F. Zengerling, N. Azoitei, L. Klein, F. Penz, S.K. Singh, T. Seufferlein, M. Hohwieler, C. Bolenz, C. Günes, J. Gout, A. Kleger. 2022. Adv Healthc Mater.
M.K. Melzer, M. Breunig, F. Arnold, F. Wezel, A. Azoitei, E. Roger, J. Krüger, J. Merkle, L. Schütte, Y. Resheq, M. Hänle, V. Zehe, F. Zengerling, N. Azoitei, L. Klein, F. Penz, S.K. Singh, T. Seufferlein, M. Hohwieler, C. Bolenz, C. Günes, J. Gout, A. Kleger. 2022. Adv Healthc Mater.
Functional genomic screening during somatic cell reprogramming identifies DKK3 as a roadblock of organ regeneration.
F. Arnold, P.U. Mahaddalkar, J.M. Kraus, X. Zhong, W. Bergmann, D. Srinivasan, J. Gout, E. Roger, A.K. Beutel, E. Zizer, U. Tharehalli, N. Daiss, R. Russell, L. Perkhofer, R. Oellinger, Q. Lin, N. Azoitei, F-U. Weiss, M.M. Lerch, S. Liebau, S-F. Katz, A. Lechel, R. Rad, T. Seufferlein, H.A. Kestler, M. Ott, A.D. Sharma, P.C. Hermann, A. Kleger. 2021. Adv Sci (Weinh)..
F. Arnold, P.U. Mahaddalkar, J.M. Kraus, X. Zhong, W. Bergmann, D. Srinivasan, J. Gout, E. Roger, A.K. Beutel, E. Zizer, U. Tharehalli, N. Daiss, R. Russell, L. Perkhofer, R. Oellinger, Q. Lin, N. Azoitei, F-U. Weiss, M.M. Lerch, S. Liebau, S-F. Katz, A. Lechel, R. Rad, T. Seufferlein, H.A. Kestler, M. Ott, A.D. Sharma, P.C. Hermann, A. Kleger. 2021. Adv Sci (Weinh)..
A prospective feasibility trial to challenge patient-derived pancreatic cancer organoids in predicting treatment response.
A.K. Beutel, L. Schütte, J. Scheible, E. Roger, M. Müller, L. Perkhofer, A.M.T.U. Kestler, J.M. Kraus, H.A. Kestler, T.F.E. Barth, J. Lemke, M. Kornmann, T.J. Ettrich, J. Gout, T. Seufferlein, A. Kleger. 2021. Cancers (Basel).
A.K. Beutel, L. Schütte, J. Scheible, E. Roger, M. Müller, L. Perkhofer, A.M.T.U. Kestler, J.M. Kraus, H.A. Kestler, T.F.E. Barth, J. Lemke, M. Kornmann, T.J. Ettrich, J. Gout, T. Seufferlein, A. Kleger. 2021. Cancers (Basel).
RINT1 regulates SUMOylation and the DNA damage response to preserve cellular homeostasis in pancreatic cancer.
F. Arnold, J. Gout, H. Wiese, S.E. Weissinger, E. Roger, L. Perkhofer, K. Walter, J. Scheible, C. Prelli Bozzo, A.Lechel, T.J. Ettrich, N. Azoitei, L. Hao, A. Fürstberger, E.K. Kaminska, K.M.J. Sparrer, V. Rasche, S. Wiese, H.A. Kestler, P. Möller, T. Seufferlein, P-O. Frappart, A. Kleger. 2021. Cancer Res.
F. Arnold, J. Gout, H. Wiese, S.E. Weissinger, E. Roger, L. Perkhofer, K. Walter, J. Scheible, C. Prelli Bozzo, A.Lechel, T.J. Ettrich, N. Azoitei, L. Hao, A. Fürstberger, E.K. Kaminska, K.M.J. Sparrer, V. Rasche, S. Wiese, H.A. Kestler, P. Möller, T. Seufferlein, P-O. Frappart, A. Kleger. 2021. Cancer Res.
Maintenance therapy for ATM-deficient pancreatic cancer by multiple DNA damage response inferences after platinum-based chemotherapy.
E. Roger, J. Gout, F. Arnold, A.K. Beutel, M. Müller, A. Abaei, T.F.E. Barth, V. Rasche, T. Seufferlein, L. Perkhofer, A. Kleger. 2021. Cells.
E. Roger, J. Gout, F. Arnold, A.K. Beutel, M. Müller, A. Abaei, T.F.E. Barth, V. Rasche, T. Seufferlein, L. Perkhofer, A. Kleger. 2021. Cells.
Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer.
J. Gout, L. Perkhofer, M. Morawe, F. Arnold, M. Ihle, S. Biber, S. Lange, E. Roger, J.M. Kraus, K. Stifter, S.A. Hahn, A. Zamperone, T. Engleitner, M. Müller, K. Walter, E. Rodriguez-Aznar, B. Sainz, P.C. Hermann, E. Hessmann, S. Müller, N. Azoitei, A. Lechel, S. Liebau, M. Wagner, D. M. Simeone, H.A. Kestler, T. Seufferlein, L. Wiesmüller, R. Rad, P-O. Frappart, A. Kleger. 2021. Gut.
J. Gout, L. Perkhofer, M. Morawe, F. Arnold, M. Ihle, S. Biber, S. Lange, E. Roger, J.M. Kraus, K. Stifter, S.A. Hahn, A. Zamperone, T. Engleitner, M. Müller, K. Walter, E. Rodriguez-Aznar, B. Sainz, P.C. Hermann, E. Hessmann, S. Müller, N. Azoitei, A. Lechel, S. Liebau, M. Wagner, D. M. Simeone, H.A. Kestler, T. Seufferlein, L. Wiesmüller, R. Rad, P-O. Frappart, A. Kleger. 2021. Gut.
DNA damage repair as target in pancreatic cancer state-of-the-art and future perspectives.
L. Perkhofer, J. Gout, E. Roger, F. Kude de Almeida, C. Baptista Simões, L. Wiesmüller, T. Seufferlein, A. Kleger. 2021. Gut.
L. Perkhofer, J. Gout, E. Roger, F. Kude de Almeida, C. Baptista Simões, L. Wiesmüller, T. Seufferlein, A. Kleger. 2021. Gut.
Schwann cells support oncogenic potential of pancreatic cancer cells through TGFβ signaling.
E. Roger, S. Martel, A. Bertrand-Chapel, A. Depollier, N. Chuvin, R.M. Pommier, K. Yacoub, C. Caligaris, V. Cardot-Ruffino, V. Chauvet, S. Aires, K, Mohkam, J-Y. Mabrut, M. Adham, T. Fenouil, V. Hervieu, L. Broutier, M. Castets, C. Neuzillet, P.A. Cassier, R. Tomasini, S. Sentis, L. Bartholin. 2019. Cell Death Dis.
E. Roger, S. Martel, A. Bertrand-Chapel, A. Depollier, N. Chuvin, R.M. Pommier, K. Yacoub, C. Caligaris, V. Cardot-Ruffino, V. Chauvet, S. Aires, K, Mohkam, J-Y. Mabrut, M. Adham, T. Fenouil, V. Hervieu, L. Broutier, M. Castets, C. Neuzillet, P.A. Cassier, R. Tomasini, S. Sentis, L. Bartholin. 2019. Cell Death Dis.
Acinar-to-ductal metaplasia induced by transforming growth factor beta facilitates KRAS-G12D-driven pancreatic tumorigenesis.
N. Chuvin, D.F. Vincent, R.M. Pommier, L.B. Alcaraz, J. Gout, C. Caligaris, K. Yacoub, V. Cardot, E. Roger, B. Kaniewski, S. Martel, C. Cintas, S. Goddard-Léon, A. Colombe, J. Valentin, N. Gadot, E, Servoz, J. Morton, I. Goddard, A. Couvelard, V. Rebours, J. Guillermet, O.J. Samsom, I. Treilleux, U. Valcourt, S. Sentis, P. Dubus, L. Bartholin. 2017. Cell Mol Gastroenterol Hepatol.
N. Chuvin, D.F. Vincent, R.M. Pommier, L.B. Alcaraz, J. Gout, C. Caligaris, K. Yacoub, V. Cardot, E. Roger, B. Kaniewski, S. Martel, C. Cintas, S. Goddard-Léon, A. Colombe, J. Valentin, N. Gadot, E, Servoz, J. Morton, I. Goddard, A. Couvelard, V. Rebours, J. Guillermet, O.J. Samsom, I. Treilleux, U. Valcourt, S. Sentis, P. Dubus, L. Bartholin. 2017. Cell Mol Gastroenterol Hepatol.